Role of FGF andNogginin Neural Crest Induction
نویسندگان
چکیده
منابع مشابه
FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction.
Neural crest induction involves the combinatorial inputs of the FGF, BMP and Wnt signaling pathways. Recently, a two-step model has emerged where BMP attenuation and Wnt activation induces the neural crest during gastrulation, whereas activation of both pathways maintains the population during neurulation. FGF is proposed to act indirectly during the inductive phase by activating Wnt ligand exp...
متن کاملPosteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction.
The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain. Here, the roles of BMPs, FGFs, Wnts, and retinoic acid signaling in neural crest induction were analyzed by using an assay developed for investigating the posteriorization of the neural plate....
متن کاملGenomic analysis of neural crest induction.
The vertebrate neural crest is a migratory stem cell population that arises within the central nervous system. Here, we combine embryological techniques with array technology to describe 83 genes that provide the first gene expression profile of a newly induced neural crest cell. This profile contains numerous novel markers of neural crest precursors and reveals previously unrecognized similari...
متن کامل04-P015 AP2α plays a central role in both neural border patterning and neural crest induction
A complex set of extracellular signals is required for neural crest (NC) specification. However, how these signals function to coordinate cell cycle progression and differentiation remains poorly understood. Here,we report inXenopus a role forStat3 inthis process downstream of FGF signaling. Depletion of Stat3 inhibited NC gene expression and proliferation while its overexpression expanded the ...
متن کامل04-P013 A temporal modulation of FGF, Wnt, BMP and Retinoic Acid signalling is required for neural crest induction
The body axes of many animals are initially patterned by the asymmetric distribution of maternal mRNAs and proteins in the oocyte. In Drosophila, these maternal factors are synthesized by the 15 nurse cells that connect to each oocyte within the ovary. However, insect ovaries fall into three anatomical categories, of which Drosophila represents only one. The telotrophic meroistic ovaries of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 1997
ISSN: 0012-1606
DOI: 10.1006/dbio.1997.8634